Three losses last week dropped Louisville to 3-9 on the season.
Leake Central earned wins of 10-0 and 15-4 against Louisville last Tuesday and Friday, respectively, and Pearl defeated the Wildcats 13-3 on Saturday.
Leake Central's Calvin McClendon tossed a no-hitter to dispatch the Wildcats on Tuesday. He struck out 13 Louisville hitters and needed 112 pitches to grab the win.
The Wildcats drew six walks, and Shemar Eiland and Braylon White ended with stolen bases.
Louisville fared a bit better against Leake Central on Friday.
Roper Stoots, Jace Hudspeth and Camden Sanders finished with hits. Hudspeth paced the Wildcats with two RBIs, while Sanders and Stoots finished with one apiece.
Eiland added his second straight stolen bases of the week, and Dre Shumaker drew a team-best two walks.
Leake Central led 5-1 at the end of the first inning en route to a 15-4 win.
Eiland tripled and doubled against Pearl on Saturday, but his hot bat wasn't enough, as the Pirates beat the Wildcats 13-3.
Stoots joined Eliand with two hits in the ballgame, while Deonte Yarbrough, Shumaker and Hudspeth tallied one hit apiece. Shumaker added two RBIs, and Yarbrough and Stoots tacked on stolen bases.
Louisville trailed Pearl 3-1 at the end of the first inning, but the Pirates offense opened for a 10-run second. The Wildcats added two runs in the third.
Louisville hosts Kosciusko on Tuesday before again facing the Whippets on the road on Friday. Louisville travels to Starkville for a doubleheader on Saturday.